Phew! Thought it was just me! I had absolutely no problem with my Saltarelle Nuage (8 basses 2 rows) but having purchased a Castagnari Mory (12 basses, 2 1/2 rows) because of the kind of music I enjoy playing, I'm finding the extra weight a bit of a problem on the left hand.
I DON'T have small hands!
so it isn't that, but if I have the strap too loose the weight of the box drags the box down and I struggle at times to reach down to the lower buttons because my hand is forced up against the strap; if I tighten it up the reverse occurs and I struggle to stretch to the top 4 buttons! Also, I then can't reach forward quickly to access the beautifully placed stops - one of the reasons I bought it in the first place!
In actual fact the problem doesn't present itself as largely as I may have made it sound, but I AM just learning this box and it does catch me out frequently and I often nearly miss the correct button.
Pikey if you could post that photo I'd love to see if it might help. And I'll re-read all the answering posts to see if I can dig something helpful out of that lot!